After calculating the mean SBP and DBP values from the two BP measurements, we adjust for medication use by adding 15 and 10 mmHg to SBP and DBP, respectively, for individuals reported to be taking BP-lowering medication (21.4% of individuals)64. PP is calculated as SBP minus DBP, according to the medication-adjusted traits. Hypertension, used in secondary analyses, is defined as: (i) SBP ≥ 140 mmHg, or (ii) DBP ≥ 90 mmHg, (iii) or taking BP-lowering medication; otherwise individuals are classified as non-hypertensive. Descriptive summary statistics are provided for all individuals (Supplementary Table 1).
