Our auxiliary genome-wide association studies of DS and neuroticism were conducted in 1000G-imputed data, combining new genome-wide association analyses with publicly available summary statistics from previously published studies. We applied a similar QC protocol to that used in our primary subjective well-being analysis. In the DS meta-analysis (N = 180,866), we weighted the UKB analysis by sample size and the two case-control studies by effective sample size. In the neuroticism meta-analysis, we performed a sample-size-weighted fixed-effects meta-analysis of the UKB data and the publicly available summary statistics from a previous GWAS of neuroticism.
