The 47 SNPs within the CHRNB3-A6 region constitute 22 LD bins using an r2 cutoff ≥ 0.8, requiring a p-value of 0.002 after Bonferroni correction. Eleven SNPs, representing four LD bins met this cutoff and are associated with DSM-5 cocaine use disorder (Table 1). Overall, a total of thirty-one SNPs were nominally significant (2.34 × 10−4 < p < 4.66 × 10−2) in this single SNP analysis. Consistent with previous results in an overlapping dataset, we saw a protective effect of rs16969968 in CHRNA5 on risk for DSM-5 cocaine use disorder [5]. Inclusion of rs16969968 as a covariate had no effect on the association of the top SNP within CHRNB3-A6, rs9298626 with DSM-5 cocaine use disorder.
