To determine whether there was evidence for multiple independently associated variants at this locus contributing to risk for DSM-5 cocaine use disorder, the most significant SNP in the region (rs9298626) was added to the model as a covariate. Conditioning on rs9298626 eliminated the association with SNPs in LD bins 1 and 2, but the association remained for SNPs in bins 4 and 5. After including rs9298626 as a covariate, the top SNP associated with this phenotype was rs892413 (p = 3.57 × 10−4, OR = 1.58, CI = 1.23–2.04). The p-value for bin 4 tagged here by rs11986892 is 0.001, OR = 1.51, CI = 1.17–1.94. Similarly the p-value for bin 5 tagged by rs10107450 is 0.003, OR = 1.45, CI = 1.14–1.85. This means that after conditioning on rs9298626, rs892413 and rs11986892 still pass the multiple test correction threshold of 0.002, whereas rs10107450 does not, although it does come close.
