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Chunk #25 — Results — The effect of age, gender, cause of death, region, PMI and brain pH on RIN-based RNA quality

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Quality control parameters on a large dataset of regionally dissected human control brains for whole genome expression studies.
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The effect of PMI on RIN differed between the MRC-UK and SHRI-USA datasets. There was no significant correlation between PMI and RIN in the MRC-UK dataset, which had PMIs ranging from 28 to 114 h. In contrast, PMI explained 8.4% of the variation in RIN in the SHRI-USA dataset (p = 0.0053), which had PMIs ranging from 1 to 5.5 h. Longer PMI was associated with a higher RIN in this data set, a counterintuitive result which might represent confounding with some unmeasured variables in the study.