significant physiological and genetic homology with humans while maintaining rigorous control over diet and other environmental cues. Moreover, immune systems of several nonhuman primate species are similar to those of humans and these animals are susceptible to several clinically important pathogens making them a valuable model to study the impact of ethanol on immunity (Hein and Griebel 2003). Nonetheless, nonhuman primate models come with their disadvantages as well. Costly requirements such as dedicated facilities to house the animals, experienced personnel to perform specialized procedures, and compliance with high standards of care must be considered.