Enrichment was seen in several brain-system related pathways, such as nicotinic acetylcholine receptors (nAChR), long-term potentiation and neurotransmitter receptor binding (Supplementary Data 20). nAChR is an important neuron receptor in which one of the subunits alpha-7 (CHRNA7) has been recently studied as a new Schizophrenia drug target52,53. nAChR was also identified as enriched pathway in the recent study using Hi-C in human cerebral cortex51 that suggests potential involvement of nAChR pathway in SCZ risk.
