Chromatin interaction mapping using Hi-C data in hippocampus and prefrontal cortex prioritized 33 genes of which DPYD and WBPIL are also mapped by a deleterious coding SNP, and VPS45 and PITPNM2 are also mapped by eQTL in the brain (Supplementary Data 18). Out of these 33 genes, 15 are located outside of the genomic risk loci. Together with positional and eQTL mapping, this resulted in a total of 113 candidate genes including 35 novel candidates which are not reported in the original study (Table 2 and Supplementary Fig. 8). The 29 genes prioritized only by chromatin interactions have shared functions with other genes such as “regulation of response to stress” (RWDD3), “intracellular signal transaction” (SGSM3), and several functions involved in regulation of transcriptions (OTUD7B and ZBTB18; Supplementary Data 19).
