as “matrisome” and “neuronal system” (Supplementary Data 19). Out of 84 prioritized genes, 60 of them were also identified by the recent TWAS50 and Hi-C51 studies including 10 genes which are physically located outside the risk loci. The prioritized genes cover 34 genomic loci out of 109 of which 20 loci are mapped to single prioritized gene (Supplementary Fig. 9; see Supplementary Note 5 and Supplementary Fig. 10 for detailed results). These 20 genes are highly likely to drive the association signal in the genomic loci. These genes include CACNA1C, LRP1, PLCB2, GRIN2A, and NMUR2, which are involved in pathways such as Alzheimer’s disease, long-term potentiation, calcium signaling, and transmission across chemical synapses.
