Top-tables and treatment-responsive modules were further assessed for the overrepresentation of cell-type specific genes. Modules or top-tables that contained more cell-type specific genes than expected by chance (hypergeometric p < 0.05) were designated as enriched for that particular cell-type. Genes were matched by gene symbols. The lists of genes that are preferentially expressed in a particular cell type were from published data. Amygdala and PFC data were queried for the following brain cell types: microglia 37, oligodendrocytes 10, astrocytes 10, neurons 10, GABAergic neurons 60 and glutamatergic neurons 60. Liver was queried for liver cell types: Kupffer, hepatocytes and hepatic stellate cells 63. The list of PPAR targets were curated from the literature and target prediction (downloaded from tfacts.org). The list of ethanol-consumption related genes was curated from mouse gene knockout, gene overexpression and microarray data (found on the INIA IT-GED website at http://inia.icmb.utexas.edu/).
