the companion paper in this issue (see 3. Brain function); and lastly those participants with genetic, neurophysiologic and comprehensive phenotypic data. The sample is middle‐aged, with slightly more female participants, notably diverse with 25%–28% from Black race/ethnic groups and 7%–8% from participants reporting Hispanic background. Over one third (35%–37%) meet criteria for DSM‐IV substance dependence on one or more substances, and Alcohol Dependence that is comorbid with other drug dependence is the most common pattern. Non‐substance disorders are common, particularly major depression, and both conduct disorder and antisocial personality disorder. The brief overview establishes the COGA sample as well‐positioned for continuing on its original path set over 30 years ago to investigate the multifaceted underpinnings and course of AUD, other addictions and related psychiatric disorders.
