In their original reports, Jones and colleagues (Jones and Smith 1973, Jones et al. 1973, Jones et al. 1976) described the features shared by a relatively small group of infants and children born to women who were clinically recognized as having an alcohol use disorder during the time frame of their pregnancy. The characteristics observed in the 11 initial cases included pre and postnatal growth retardation (100%), developmental delay or mental deficiency (100%), and distinct craniofacial anomalies, including short palpebral fissures (100%) and maxillary hypoplasia (64%), joint and palmar crease anomalies (73%), and cardiac defects (70%).
