Promising pathways emerging from our exploratory pathway analysis were defined as those meeting nominal significance before correcting for multiple testing in CADD and either MCTFR or SAGE samples (Empirical p<0.05). Two pathways met these criteria: visual perception (Empirical pCADD=0.038, pMCTFR=0.012, pSAGE=0.22) and phosphatidylcholine biosynthetic process (Empirical pCADD=0.039, pMCTFR=1.0, pSAGE=0.026). Neither pathway achieved marginal significance in any sample after correction for multiple testing (i.e., Corrected p<0.10). Supplemental Table S4 provides results from all 72 pathways meeting Empirical p<0.05 in CADD (from a total of 3440 pathways tested) that were subsequently tested in the MCTFR and SAGE samples.
