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Chunk #20 — Schizophrenia

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The use of current source density as electrophysiological correlates in neuropsychiatric disorders: A review of human studies.
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enabled comparison of the amplitudes of hemisphere-related components in two or more groups (Spencer et al., 1999, 2001; Tenke et al., 2008). Extending the study to include unaffected siblings, Turetsky et al. (2000) reported that both schizophrenic patients and unaffected siblings showed significant P3-related CSD reductions at the parietal and frontal P300 subcomponents compared to the healthy controls (patients < unaffected siblings < healthy controls). Interestingly, undiagnosed individuals with high schizotypal scores showed decreased P3-related CSD activation at the parietal (Pz) region for the target and novel conditions in an auditory oddball task as compared to the low-scoring participants (Klein et al., 1999).