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Chunk #18 — OVERVIEW OF EXTANT GENETIC RESEARCH ON ALCOHOL USE OUTCOMES IN AFRICAN AMERICAN POPULATIONS — Measured Genotypic Studies

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Review: Genetic research on alcohol use outcomes in African American populations: A review of the literature, associated challenges, and implications.
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genetic research to ensure this group equally benefits from health advances related to genetic findings. The new initiative on precision medicine,16 emphasizing the use of large-scale biologic databases including genetic information, makes it imperative that we ensure all populations are adequately represented in the research to ensure that all will benefit equally. It is critical to include representation across diverse populations as we build the research base that will support the precision medicine initiative. Although our understanding of the genetics of alcohol dependence remains in an early stage, with few replicated genetic variants currently identified, GWAS of other complex traits are beginning to account for nontrivial amounts of genetic variance (height= ~29%, schizophrenia=~7%).49,50