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Chunk #64 — Discussion — Study goals and findings

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A stable pattern of EEG spectral coherence distinguishes children with autism from neuro-typical controls - a large case control study.
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The second goal was to evaluate the consistency of subject classification by allowing DFA to select the best factors for discrimination. As discussed in Results the average jackknifed classification success for the three separate age-group DFAs was 93.7% for the control- and 97.0% for the ASD-group. When the entire population was subjected to 10 independent split half replications, classification success was on the average 88.5% correct for the C- and 86.0% correct for the ASD-groups. Moreover, when each training-set-generated discriminant function was evaluated against the corresponding test-set by t-test, every one of the 10 control- versus ASD-group comparisons reached probability levels of P < 0.0001 levels. These findings thus establish coherence factors as very useful in subject classification. They, furthermore, establish the substantial stability of the reported coherence findings and argue quite strongly against great inter-subject variability in this study's ASD population. The illustrated factor coherence loading patterns (Figure 2) appear to constitute a potentially useful neurophysiological ASD-phenotype. Furthermore, the demonstrated stability of the above coherence findings argues against marked variability of brain function within the ASD population as postulated by Happé [32] and Milne [33].