The PFC is a heterogeneous region comprising several areas that are distinct at the cytoarchitectural and functional levels.[34] The lateral PFC, usually referred to as the dorsolateral PFC (DLPFC) is considered the central executive for cognitive control, whereas the orbital PFC (OPFC) is considered the central executive for emotional and social control.[5] Finally, the medial PFC (MPFC) is thought to mediate drive and motivation.[67] Specific neurobehavioral syndromes linked to preferential involvement of each of these three circuits have been described.[8] These include the dysexecutive syndrome, the disinhibition or the pseudopsychopathic syndrome, and the apathetic or pseudodepressive syndrome, that are linked to the dorsolateral prefrontal, orbitofrontal, and anterior cingulate FSCs, respectively.[68] These syndromes, along with behavioral disorders associated with dysfunction of brain areas that are connected to these circuits through open connections, bear striking resemblance to the symptom dimensions and neurocognitive dysfunction observed in the group of conditions which we collectively refer to as schizophrenia. The most important among these areas which are linked to the FSC through open connections is the temporo-limbic cortex. The connections between the temporo-limbic cortex and
