For perspective, power computations using the observed distribution of top effects for other large GWAS of polygenic traits suggest that we observe significantly fewer genome-wide significant loci for AD than would be expected if the loci had true effect sizes and allele frequencies similar to schizophrenia (expected: 25.4 loci, 95% CI 21-30) or obesity (expected: 8.9 loci, 95% CI 6-12), but not fewer than would be expected for effect sizes similar to major depression (Supplementary Information A10, Supplementary Table S8).
