Power analyses indicated that the current meta-analysis is expected to have at least 41% power to detect very common variants (MAF ≥ 0.25) with odds ratios ≥ 1.10 at p < 5E-8 and 63% power for p < 1E-6 (Supplementary Figure S11). Power at p < 1E-6 is relevant because only 5 loci reach that threshold in the current meta-analysis. Power is lower for less common variants (MAF ≤ 0.05) even with odds ratios ≥ 1.20 at p < 1E-6 (60% power) and p < 5E-8 (38% power).
