As shown in Table 2, a significant (corrected p < .025) genotype × traumatic stress interaction on the likelihood of developing alcoholism was found for the block two SNPs rs173365 and rs17689966 that are in allelic identity (MAF = 0.428-0.429). Results of the full models for each of the two SNPs are presented in Table 5. As can be seen in Table 3b, base pairs for SNPs rs173365 and rs17689966 differ from the reference haplotype in both H1 and H7 haplotypes. However, these loci do not differ from H3, H5, and H6 suggesting that these SNPs alone do not account for the observed haplotype effects. Therefore, epistatic effects and/or additional markers not captured in these analyses likely contribute to the haplotype results observed for block 2. In models examining three-way interactions between genetic factors, trauma and sex, which included all lower order interaction terms, there were no significant three-way CRHR1 SNPs/haplotypes × Traumatic Stress × Sex interactions (ps > .10).
