To further elucidate the putative role of stress dysregulation in the CRF system in the initiation and maintenance of addiction (Koob & Kreek, 2007), this study examined CRHR1 G × E interactions as predictors of alcoholism status in a large and well-defined sample of Caucasians. In contrast to many of the CRHR1 G × E studies in depression, our stressor was trauma experienced in adulthood rather than childhood. This is in common with several of the CRHR1 G × E studies on alcoholism and alcohol consumption phenotypes that have had positive outcomes (e.g., Blomeyer et al., 2008, Schmid et al., 2010).. As shown in Table 4, the haplotype block 1 H1 haplotype had both a main effect and an interactive effect with trauma on risk for AD. Specifically, in individuals not exposed to trauma, the H1/H1 diplotype was found to be a risk factor for AD relative to the H2/H2 diplotype; however, with trauma exposure carriers of the H1/H1 diplotype were found to be more resilient to the development of AD relative to H2/H2 carriers. A similar pattern of results
