A similar pattern of results emerged for haplotype block 2 (see Table 6). There was a simple effect of sex and trauma (ps < .0001), such that males and trauma-exposed individuals were more likely to meet criteria for alcoholism. Further, there were simple effects for two haplotypes (H1, trend level, and H7), which were associated with increased risk of AD. In addition, there were significant haplotype × trauma interactions for both H1 and H7 (p = .026 and .042, respectively) such that the effects of traumatic stress exposure on alcoholism risk were mitigated by the H1 haplotype. As shown in Figure 3, in individuals not exposed to trauma, the H1/H1 diplotype is a risk factor for AD relative to the H4/H4 diplotype; however with trauma exposure, carriers of the H1/H1 diplotype are more resilient to the development of AD relative to H4/H4 carriers.
