4 × 10−3) and axon ensheathment (FDR < 7 × 10−3) (Supplementary Table S4). Genes in the neuron part category included Adora1, Chrna4, Crhr1, Drd1a, Gabbr2, Gabrd, Gal, Htr1a, Htr2a, Htr7, Pde1b, Reln, Syt2, and Tac1. The CeA DE genes were significantly (corrected p < 8 × 10−7) enriched in the yellow network module (Supplementary Table S2). The yellow module was enriched in annotations associated with plasma membrane (FDR < 5 × 10−4), regulation of nervous system development (FDR < 4 × 10−4) and structural constituent of myelin sheath (FDR < 9 × 10−3; Supplementary Table S4). The average relative intramodular connectivity (full scale – 0.0 to 1.0) for the yellow module DE genes in the Low and High lines was 0.30 and 0.31, respectively (see Supplementary Table S3). Five of the 109 DE yellow module genes were hub nodes (relative connectivity >0.80 in either the High or Lines or both lines). These genes were Rbm24, Dock10, Prkcd, Rap1gap, and Spg2.
