There were 398, 302, and 183 genes showing significant (adjusted p-value < 0.05) DE between the High and Low selected lines in the CeA, SH, and PL, respectively (Supplementary Table S3). The overlap in DE is illustrated in Figure 3. Only five genes (5730455P16Rik, Gdi2, Skiv2, Tsr1, and Glod4), all with increased expression in the High line, showed common DE. The overlap for DE was highest between the SH and CeA (N = 31). Genes in all the overlapping categories are listed in Supplementary Table S3. Only one gene showed a difference in the direction of DE between regions; Doc2b showed increased/decreased expression in the High line (PL vs. SH). GO annotation of the CeA DE genes revealed a significant enrichment in genes associated with the neurononal component (FDR < 3 × 10−5), structural constituent of myelin sheath (FDR < 4 × 10−3) and axon ensheathment (FDR < 7 × 10−3) (Supplementary Table S4). Genes in the neuron part category included Adora1, Chrna4, Crhr1, Drd1a, Gabbr2, Gabrd, Gal, Htr1a, Htr2a, Htr7, Pde1b, Reln, Syt2, and Tac1. The CeA DE genes
