We also utilized a complementary module preservation measure which is tabulation-based and uses the Fisher exact test. This measure evaluates whether the intersection of two modules originating from different brain regions is greater than what can be expected by chance. We found that in most cases each module has one or at most 2–3 counterparts in different brain regions (Figure 2). When overlaying the DE/DV/DW information on the module overlap, a complex picture emerges. We have examples of counterpart modules being affected across region, for example the DW CeA blue module having a very strong counterpart in the DE SH lightgreen module (Figure 2A). Another example of concordance across regions includes the DE, DV, and DW SH magenta module having a strong counterpart in the DV, DW PL brown module (Figure 2C). The clearest example of lack of concordance is the DE, DV, DW SH magenta module with no counterpart in the CeA (Figure 2A).
