Utilizing the tabulation-based module preservation procedure, we quantified the extent to which modules overlap across regions. The vast majority of modules were preserved across regions (Z summary > 2), as described in Langfelder et al. (2011). There were a few exceptions: the CeA modules cyan, greenyellow, midnightblue, and yellow were either not preserved or only mildly preserved (2 < Z summary < 3) in both SH and PL. The SH modules grey60 and lightgreen were not preserved in either CeA or PL; additionally SH lightcyan was not preserved in CeA. The PL module midnightblue was not preserved in the CeA. The rest of the modules were either preserved (2 < Z summary < 10) or in most cases highly preserved (Z summary > 10). These results illustrate that transcriptional network organization is overall preserved across brain regions, although the strength of interaction varies.
