We examined 46 SNPs in 19 loci identified in recent GWAS in European-derived populations for association with obesity in six African-American cohorts. Meta-analysis revealed seven SNPs (rs94224977, rs3101336, rs2568958, rs2867125, rs7498665, rs477181 and rs4450508) located at, or near the four loci (NEGR1, TMEM18, SH2B1 and MC4R), showing suggestive association with BMI (0.005<P<0.05) (Table 2). Although none of the SNPs showed significant association across all six cohorts due to modest sample size, the consistent direction of association with the European data may indicate their role in the modulation of BMI levels in African Americans.
