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Chunk #20 — RESULTS — Effects of ethanol on gene expression

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Ethanol treatment of lymphoblastoid cell lines from alcoholics and non-alcoholics causes many subtle changes in gene expression.
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Not unexpectedly, sex had a significant effect on gene expression: 122 probe sets, associated with 58 unique named genes, were expressed differently in cells from males than in cells from females, FDR ≤ 0.05 (nominal p-value ≤ 2×10−4). This list includes genes such as XIST, EIF1AX, which are not detectably expressed in males, and EIF1AY, DDX3Y and NLGN4Y, which were not detectably expressed in females. Of these 58 loci, 48 mapped to either the X or Y chromosome.