from an electrode located about a 1 mm away. Figure 4D shows the relationship between the distance from stimulation to recording electrode and the duration of saturation for a 11,011-electrode MEA (Frey et al., 2010), without employing any artifact suppression measures. As long as the amplifiers do not fully saturate, it is possible to suppress such artifacts in software by subtracting the estimated artifact (based on templates, filters or local curve fitting) from the data (Hashimoto et al., 2002; Wagenaar and Potter, 2002). To also allow recording from electrodes on which saturation would occur, counter measures in hardware have to be employed. One solution is to use a “reset” switch that can bring back the saturated amplifier into normal operation quickly, by resetting the high-pass filter of the front-end amplifier (Heer et al., 2006; Frey et al., 2010). To suppress artifacts even on the stimulation electrode itself, more sophisticated methods are used. Jimbo et al. proposed a method to decouple the recording amplifiers during stimulation, sample the electrode potential during recording and add the stimulation pulse to the stored electrode potential (Jimbo et al., 2003). This scheme has also been implemented on dedicated ASICs to be used in conjunction with
