In order to probe the biological relevance of our four BRAINSPAN clusters, we compared these gene lists to known and candidate gene sets with relevance to schizophrenia55. Genes in clusters A and B, (i.e., clusters with pre-natal expression) were involved in brain morphology and development, nervous system development, neuron development and morphology and synaptic development, function, and morphology (Supplementary Table 4). These associations were not seen in clusters C and D (i.e., genes with late pre-natal and post-natal expression).
