and fOT indicated the existed gender difference of brain functional connectivity in resting-state [26–28]. Nevertheless, there were few studies of gender-related effects in resting-state functional connectivity via fOT monitoring. Thus, we hope to further investigate the gender-related effects of PFC connectivity in the resting-state by using fOT method in this study. The hemoglobin responses were filtered within 0.01 to 0.08 Hz for statistically evaluation of the PFC region in the resting-state. The functional connectivity and cortical lateralization of gender-related effects are then evaluated by using time series of the total hemoglobin response. The power spectrum analysis was used to estimate the significantly different of PFC regions between male and female groups. The results show that the gender-related effects of resting-state fOT measurement should be considered necessarily for group-level analysis.
