Table 2 presents the results of the survival analyses, with the hazard ratios of AD (adjusted for age, sex, education, and ethnicity) and the 95% confidence intervals associated with each factor and facet. For each SD increase in neuroticism, the risk of incident AD increased by more than 30% (HR = 1.37; 95%CI =1.09–1.73). We contrasted groups with high and low scores on neuroticism and found that the risk of incident AD was threefold higher for the group in the highest quartile compared to the lowest quartile of neuroticism (HR = 3.13; 95%CI = 1.62–6.04; see Figure 1). The absolute risk, which does not account for covariates or censoring, was 7% and 3% for the highest and lowest quartiles of neuroticism. Further, we calculated that over 10% of the AD cases in the population could be attributed to high neuroticism (top quartile vs. others; HR = 2.02; PAR = 13%). A similar effect was observed for conscientiousness (HR = 0.69; 95%CI =0.55–0.87), and as illustrated in Figure 1, the risk of incident AD was threefold higher for the group in
