Chunk #42 — Online Methods — Genome-wide survival association study datasets — (4) Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)
Cardiovascular Health Study (CHS): The CHS is a prospective population-based cohort study of risk factors for vascular and metabolic disease that in 1989–90, enrolled adults aged ≥65 years, at four field centers located in North Carolina, California, Maryland and Pennsylvania. The original predominantly Caucasian cohort of 5,201 persons was recruited from a random sample of people on Medicare eligibility lists and an additional 687 African-Americans were enrolled subsequently for a total sample of 5,8882. DNA was extracted from blood samples drawn on all persons who consented to genetic testing at their baseline examination in 1989–90. In 2007–2008, genotyping was performed at the General Clinical Research Center’s Phenotyping/Genotyping Laboratory at Cedars-Sinai using the Illumina 370CNV Duo ® BeadChip system on 3,980 CHS participants who were free of cardiovascular disease (CVD) at baseline. The 1,908 persons excluded for prevalent CVD had prevalent coronary heart disease (n=1,195), congestive heart failure (n=86), peripheral vascular disease (n=93), valvular heart disease (n=20), stroke (n=166) or transient ischemic attack (n=56). Some persons had more than one reason to be excluded and for these individuals only the initial
