Chunk #43 — Online Methods — Genome-wide survival association study datasets — (4) Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE)
coronary heart disease (n=1,195), congestive heart failure (n=86), peripheral vascular disease (n=93), valvular heart disease (n=20), stroke (n=166) or transient ischemic attack (n=56). Some persons had more than one reason to be excluded and for these individuals only the initial exclusionary event is listed. Because the other cohorts were predominantly white, the African American CHS participants were excluded from this analysis to limit errors secondary to population stratification. Among white participants genotyping was attempted in 3,397 participants and was successful in 3295 persons. After excluding persons that had either died prior to the start of the CHS cognition study in 1992 (see section 3 for details), could not be evaluated completely for baseline cognitive status, and persons that had dementia other than AD, a sample of 2,049 persons was available. The CHS study protocols were approved by the Institutional review boards at the individual participating centers.
