We found significant enrichment of CENTRAL NERVOUS SYSTEM for all three phenotypes and, perhaps more surprisingly, enrichment of ADRENAL/PANCREAS for subjective well-being and depressive symptoms. The cause of the ADRENAL/PANCREAS enrichment is unclear, but we note that the adrenal glands produce several hormones, including cortisol, epinephrine, and norepinephrine, known to play important roles in the bodily regulation of mood and stress. It has been robustly found that blood serum levels of cortisol in patients afflicted by depression are elevated relative to controls28.
