Next, to investigate whether our GWAS results are enriched in particular functional categories, we applied stratified LD Score regression26 to our meta-analysis results. In our first analysis, we report estimates for all 53 functional categories included in the “baseline model”; the results for subjective well-being, depressive symptoms, and neuroticism are broadly similar (Supplementary Tables 18–20) and are in line with what has been found for other phenotypes26. In our second analysis, the categories are groupings of SNPs likely to regulate gene expression in cells of a specific tissue. The estimates for subjective well-being, depressive symptoms, and neuroticism are shown in Figure 4a, alongside height, which is again included as a benchmark27 (see also Supplementary Table 21).
