We estimated the genetic correlations between PAU and 715 publicly available sets of GWAS summary statistics, which included 228 published sets and 487 unpublished sets from the UK Biobank. After Bonferroni correction (p < 6.99 × 10−5), 138 traits were significantly correlated with PAU (Supplementary Table 8). Among the 26 published correlated traits, drinks per week showed the highest correlation with PAU (rg = 0.77, se = 0.02, p = 3.25 × 10−265), consistent with the overall quantity of alcohol consumed being a key domain of PAU [5, 19]. Several smoking traits and lifetime cannabis use were positively genetically correlated with PAU, consistent with the high comorbidity between alcohol and other substance use disorders in the general population [20]. Among psychiatric disorders, major depressive disorder (MDD, rg = 0.39, se = 0.03, p = 1.43 × 10−40) showed the highest genetic correlation with PAU, extending the evidence for a shared genetic contribution to MDD and alcohol-related traits [21, 22]. PAU was positively correlated with risk-taking behavior, insomnia, CYP2A6 activity, and other traits, and negatively correlated with cognitive traits and parents’
