Chunk #27 — RESULTS — DG-like hippocampal neurons derived from BD patients are hyperexcitable, but the intrinsic properties of LR and NR neurons are profoundly different
were 21% narrower in LR and 18% wider in NR compared with control neurons (P = 0.0475 control to LR, P = 0.15 control to NR and P = 0.0002 LR to NR) (Supplementary Figure 1h). The threshold for evoking a spike was 6 mV more depolarized in NR (P<0.0001 for both control to NR and LR to NR) (Supplementary Figure 1i). This finding seems at odds with the neurons’ hyperexcitability, but excitability is a combination of many factors. For example, Down syndrome model neurons have been shown to have a less depolarized threshold, yet they are hypoexcitable.56 Input conductance is also an important player in cell excitability.57 A cell with lower conductance synaptic current inputs will cause a larger change in the membrane potential (through Ohm’s law), so lower currents are needed to reach the threshold for spiking. There was no change to the input conductance in BD neurons (Supplementary Figure 1j). Capacitance was slightly increased for BD neurons (Supplementary Figure 1k) but not significantly in this data set.
