Chunk #26 — RESULTS — DG-like hippocampal neurons derived from BD patients are hyperexcitable, but the intrinsic properties of LR and NR neurons are profoundly different
in which the potassium channels open. In addition, there are more factors, for example, the sodium currents are increased (at −40 mV, there is ~ 80%, P = 0.15 more sodium currents in the LR neurons than the controls), additionally the kinetics of the channels is faster (the rise time, the time it takes the spike to reach the maximum, is decreased in LR neurons and is 2.4 ± 0.2 ms in LR vs 2.8 ± 0.2 ms in controls, P = 0.13). The combination of faster channels that open at a less depolarized potential allow for the spike height to be significantly larger in LR neurons. It should also be noted that taking the area under the sodium currents curve from −60 to −20 mV is ~ 20% increased in LR neurons, similar to the increase in spike height. The fast 5-ms AHP was larger for BD neurons (but not significantly in this data set) (Supplementary Figure 1g). Spikes were 21% narrower in LR and 18% wider in NR compared with control neurons (P = 0.0475 control to LR, P = 0.15 control to NR and P = 0.0002 LR to NR) (Supplementary Figure 1h). The threshold for evoking
