Exploratory bivariate correlations among binge drinkers, uncorrected for multiple comparisons, were run to determine if areas of group differences in FA were associated with alcohol involvement. More lifetime alcohol hangover/withdrawal experiences were related to lower FA in the corpus callosum (Cluster 2: r = −0.65, p < 0.025; Cluster 4: r = −0.71, p < 0.025; and Cluster 5: r = −0.60; p < 0.025; see Fig. 2), and trends were found in the left anterior corona radiata (Cluster 1: r = −0.50, p = 0.06) and left inferior cerebellar peduncle (Cluster 12: r = −0.50; p = 0.06). Peak estimated blood alcohol concentration in the 3 months prior to scanning was also inversely related to FA in the body of the corpus callosum (Cluster 5: r = −0.54, p < 0.05), left internal and right external capsules (Cluster 9: r = −0.53, p < 0.05; and Cluster 10: r = −0.59, p < 0.025), and left posterior corona radiata (Cluster 14: r = −0.62, p < 0.025). No relationships were observed between FA and lifetime drinks, and duration of drinking.
