Here, we examined whether γ (normalized clustering coefficient) might prove sufficiently sensitive and specific to serve as a biomarker for AD. Using the cut-off value (γ = 1.57) that maximizes sensitivity and specificity, γ correctly classified 14 out of 18 controls and 15 of 21 AD subjects, yielding 72% sensitivity and 78% specificity respectively. A receiver operating characteristic curve for various cut-off values is shown in Figure 4. The Area Under the Curve for the ROC was 0.754 (95% CI Area 0.602 to 0.906).
