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Chunk #24 — Results — Post-Hoc tissue enrichment

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Differences in genetic correlations between posttraumatic stress disorder and alcohol-related problems phenotypes compared to alcohol consumption-related phenotypes.
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In EA samples, only the GWAS from MVP PTSD Re-experiencing symptoms, Drinks Per Week (GSCAN and UKB) and Drinks Per Week (UKB) met the FDR significance threshold for specific tissue enrichment (see online Supplementary Fig. S3). These three GWAS that met for this threshold exceeded the FDR significance value for only tissues having to do with the brain (i.e. not other tissues). In AA samples, none of the included GWAS met the FDR threshold for significance for tissue enrichment (see online Supplementary Fig. S4).