For PCL-Total, we identified 15 GWS loci in the EUR population. For the case-control phenotype, we observed three loci in the EUR population and two loci in the AFR population. Each locus that included more than 10 GWS SNPs was fine-mapped27 to prioritize variants in each locus, defined as credible sets (Supplementary Data 1). Regions associated with PCL-Total scores had multiple variants with Combined Annotation Dependent Depletion (CADD) scores > 10 (i.e., these variants were among the top 10% of pathogenic variants across the human genome)28. For example, in the region Chr3:49734229–50176259, associated with PCL-Total, there were four sub-regions with one or more exonic SNPs with CADD scores > 10. CAVIAR (Causal Variants Identification in Associated Regions)27 fine-mapping results and CADD scores are included in Supplementary Data 1.
