The MVP surveys included the PTSD Checklist for DSM-IV (PCL), a widely used 17-item self-report measure of past-month PTSD symptoms covering the three DSM-IV symptom cluster criteria – re-experiencing, avoidance, and hyperarousal – and a total symptom severity score (PCL-Total) as the sum of those three sub-phenotypes26. GWAS with these phenotypes in the EUR sample (n = 186,689 individuals) using linear regression identified multiple independent GWS SNPs, including some that were associated with PCL-Total as well as multiple sub-domains, and others that were more strongly associated with specific sub-domains (Table 1). Overlap in risk loci for the case-control and the quantitative phenotypes in the EUR and AFR samples is shown in Figure 2. Supplementary Table 5 shows PCL-Total GWAS results in the trans-ancestral sample.
