To understand the biological effect of SNPs associated with PTSD phenotypes, we analyzed top SNPs (at suggestive threshold P < 5 × 10−6) for their distinct and overlapping distribution across the four sub-phenotypes. The top SNPs for each phenotype were LD pruned to obtain independent signals. We found 87 (hyperarousal), 49 (avoidance), 62 (re-experiencing), and 36 (PCL-Total) SNPs that were non-overlapping or phenotype-specific (Supplementary Data 2). These non-overlapping SNPs were assessed for their QTL protein associations (all tissues), DNA methylation (brain tissues), and splicing (brain tissues) from the QTLbase29. Most of the QTL associations were observed for methylation expression. These QTL associations are shown as Venn diagrams for each phenotype (Supplementary Data 2); detailed tabular results are also shown in Supplementary Data 2.
