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Chunk #26 — Results — Joint analysis for dichotomous CPD

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Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.
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For locus 1 and locus 4 in the joint model, locus 1 gives p = 1.01×10−38, OR = 1.35 (1.29–1.41) and locus 4 gives p = 5.55×10−3, OR = 1.17 (1.05–1.31). While the effect for locus 4 is stronger than was seen in single-SNP analysis, it does not meet our multiple test threshold for significance. In single-SNP analysis of the 25 datasets that have genotypes at both loci, locus 1 alone gives p = 7.56×10−35, OR = 1.33; locus 4 is non-significant (p = 0.45, OR = 1.05).