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Chunk #27 — Results — Lung cancer controlled for CPD

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Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.
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In Table 7 we report the single-SNP meta-analysis results for the six lung cancer datasets; recall that all subjects were smokers, and sex, age and categorical CPD were included as covariates. As with the CPD traits, locus 1 (rs16969968) shows highly significant evidence for association with lung cancer (p = 1.99×10−21). The summary odds ratio of 1.31 (1.24–1.38) closely matches the dichotomous CPD odds ratio of 1.33 (1.26–1.39). Figure 4 shows the association results for locus 1 by dataset and the overall meta-analysis results.