There was no significant enrichment in any GO annotation for the DE genes in the PL. This group of genes was however, significantly enriched (p < 4 × 10−5) in the PL turquoise network module. This module was enriched in genes with the Rho GTPase binding annotation (FDR < 6 × 10−3). The average relative intramodular connectivity for these DE genes in the Low and High lines was 0.43 and 0.32, respectively (p < 0.003). Five of the 83 DE turquoise module genes were hub nodes. These genes were Mapk7, Pcgf2, Leng2, Col5a3, and Pabpn1.
