There were 424, 479, and 236 genes showing significant (adjusted p-value < 0.05) DV between the High and Low selected lines in the CeA, SH, and PL, respectively (Supplementary Table S5). The overlap in DV is illustrated in Figure 3C. Thirty genes were common to all three regions and this grouping was significantly (FDR < 3 × 10−3) enriched in genes associated with cell-to-cell signaling. Genes with this GO annotation included Dlg2, Egr3, Gabbr2, Lnpep, Pcdhgb2, Pcdhac2, Sstr4, and Syt10. The overlap in genes (N = 44) between the PL and SH showed a significant enrichment in genes with the GO annotation of neuron projection (FDR < 6 × 10−3). Genes with this GO annotation included Bace1, Cpeb3, Fzd3, Igf1r, Igsf9, Kcna3, Kcnb1, Kcnma1, Slc8a1, Sv2c, Tenm1, and Tenm3. In all three regions the direction of the DV was High line > > Low line.
