GO annotation of the CeA DV genes revealed a significant enrichment in genes associated with cell-to-cell signaling (FDR < 3 × 10−4; Supplementary Table S7). Genes in this category and not already noted above included Chat, Gabrg3, Glra3, Gpr88, Ntrk2, Pten, Sdcbp, and five additional protocadherins. The CeA DV genes were significantly (1 × 10−8) enriched in a single network module, blue. Annotations for the blue module included synaptic membrane (FDR < 5 × 10−2) and cell-to-cell signaling (FDR < 2 × 10−7; Supplementary Table S6). The blue module contained most of the cell-to-cell signaling genes noted above and included Chrm5, Chrna7, Chrnb2, Grid1, Grik3, Grin2a, Grin2b, Htr5a, and Sv2c; the module was also associated with 16 protocadherin genes. For the blue module DV genes, intramodular connectivity was significantly different between the Low and High lines (0.32 vs. 0.48, p < 1 × 10−16). The most prominent change in connectivity for non-hub to hub status was seen for Ntrk2 (0.197 vs. 0.821; Low vs. High line). Nrtk2 encodes TrkB, a receptor for Bdnf.
